PAPER: A modular approach to DNA-programmed self-assembly of macromolecular nanostructures

Gothelf, K. V.; Brown, R. S.

Chem. Eur. J. 2005, 11, 1062–1069.

Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark


DNA-programmed organic reactions are new and powerful tools for assembling chemical compounds into predetermined complex structures and a brief review of their use is given. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA-templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA-programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds. Some future developments in this area are discussed.

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