PAPER: DNA-programmed assembly of nanostructures

Gothelf, K. V.; LaBean, T. H.

Org. Biomol. Chem. 2005, 3, 4023–4037, doi: 10.1039/B510551J

Department of Chemistry, Aarhus University, Langelandsgade 140, Aarhus C, Denmark

Department of Computer Science, Duke University, Durham, USA


DNA is a unique material for nanotechnology since it is possible to use base sequences to encode instructions for assembly in a predetermined fashion at the nanometre scale. Synthetic oligonucleotides are readily obtained by automated synthesis and numerous techniques have been developed for conjugating DNA with other materials. The exact spatial positioning of materials is crucial for the future development of complex nanodevices and the emerging field of DNA-nanotechnology is now exploring DNA-programmed processes for the assembly of organic compounds, biomolecules, and inorganic materials.

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