PAPER: Model systems for activation of nucleic acid encoded prodrugs

Jacobsen, M. F.; Cló, E., Mokhir, A.; Gothelf, K. V.

ChemMedChem 2007, 2, 793–799, doi: 10.1002/cmdc.200700013

Centre for DNA Nanotechnology, Center for Catalysis and Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark.

Abstract

The development of more selective chemotherapeutic agents for benign treatments of malicious diseases is highly desirable. In recent years model systems for the release of small molecule drugs from nucleic acid conjugates by templated chemical or photochemical reactions have been designed. Common for these systems is that the stoichiometric or catalytic drug release is controlled by the highly selective hybridization between complementary strands of nucleic acids. Herein, the concepts of the new field of nucleic acid templated release reactions are outlined.

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