PAPER: Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods

Andersen, C. S.; Yan, H.; Gothelf, K. V.

Angew. Chem. Int. Ed. 2008, 47, 5569–5572, doi: doi: 10.1002/anie.200800819

Danish National Research Foundation, Centre for DNA Nanotechnology, Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark.

Abstract

A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10-base-pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal–salen complex

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