Andersen, C. S.; Gothelf, K. V.
Org. Biomol. Chem. 2009, 7, 58–60, doi: 10.1039/B815099K
Danish National Research Foundation: Centre for DNA Nanotechnology, Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO), Langelandsgade 140, 8000 Aarhus C, Denmark
We are presenting the synthesis of a phenylene ethynylene-based rod containing an Fmoc protected amino group and an activated acid which can be applied to peptide couplings. This linear amino acid analogue is applied to the synthesis of di-, tri- and pentamers. The pentamer has a molecular mass of 6.5 kDa and is characterized by 1H NMR spectroscopy and MALDI-TOF MS. The method has potential for the formation of long macromolecular oligomers.