PAPER: Small molecule induced control in duplex and triplex DNA-directed chemical reactions

Jacobsen, M. F.; Ravnsbæk, J. B.; Gothelf, K. V.

Org. Biomol. Chem. 2010, 8, 50–52, doi: 10.1039/B919387A

Danish Research Foundation: Centre for DNA Nanotechnology at the Interdisciplinary Nanoscience Center and the Department of Chemistry, AarhusUniversity, Langelandsgade 140, 8000 Aarhus C, Denmark


Triplex DNA binders can effectively control copper-catalysed alkyneazide click reactions in DNA architecture, such that either duplex or triplex DNA directed reactions of terminally attached azides and alkynes occur, in the absence or presence of triplex DNA binder, respectively.

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