Efficient colorimetric and fluorescent detection of fluoride in DMSO–water mixtures with arylaldoximes

Rosen CB, Hansen DJ, Gothelf KV.
Org Biomol Chem. 2013 Dec 7;11(45):7916-22. doi: 10.1039/c3ob41078a. Epub 2013 Oct 17.
Danish National Research Foundation, Center for DNA Nanotechnology, Department of Chemistry and iNANO, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark. kvg@chem.au.dk.


Fluoride detection through hydrogen bonding or deprotonation is most commonly achieved using amide, urea or pyrrole derivatives. The sensor molecules are often complex constructs and several synthetic steps are required for their preparation. Here we report the discovery that simplearylaldoximes have remarkable properties as fluoride anion sensors, providing distinct colorimetric or fluorescent readouts, depending on the structure of the arylaldoxime. The oximes showed exceptional selectivity towards fluoride over other typical anions, and low detection limits for fluoride in both DMSO and DMSO-water mixtures were obtained.

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