Paper: Function and Movement of a DNA Actuator Investigated by Single Molecule Fret Microscopy.

Hildebrandt, LL., Zhang, Z., Preus, S., Gothelf, KV., Birkedal, V.

Biophys. J. 2014, 106 (2), 226a,

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark


DNA is an interesting building block for the construction of active nanoscale devices. Movement in these structures is typically achieved through conformational changes that can be driven by DNA fuel strands or by internal changes in DNA hybridization. In this study we investigate the function and fidelity of a DNA actuator with 11 states using single molecule FRET microscopy. The DNA actuator is a complex molecular DNA device capable of finely controlled actuation through the movement of its two DNA piston arms, see the included figure.

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